Expresión de búsqueda:
UNFOLDED PROTEIN RESPONSE
Descriptores Encontrados:
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DeCS
Descriptor
Inglés
:
Unfolded Protein Response
Descriptor
Español
:
Respuesta de Proteína Desplegada
Descriptor
Portugués
:
Resposta a Proteínas não Dobradas
Sinónimos
Inglés
:
Protein Response, Unfolded
Protein Responses, Unfolded
Response, Unfolded Protein
Responses, Unfolded Protein
Unfolded Protein Responses
Categoría:
G02.111.660.871.790.600.962
G02.111.691.600.850
G03.734.871.790.600.850
G05.308.670.600.850
Definición
Inglés
:
A cellular response to environmental insults that cause disruptions in
PROTEIN FOLDING
and/or accumulation of defectively folded protein in the
ENDOPLASMIC RETICULUM
. It consists of a group of regulatory cascades that are triggered as a response to altered levels of
calcium
and/or the redox state of the
endoplasmic reticulum
. Persistent activation of the
unfolded protein response
leads to the induction of
APOPTOSIS.
Relacionados
Inglés
:
Endoplasmic Reticulum Stress
Endoplasmic Reticulum-Associated Degradation
Nota Histórica
Inglés
:
2010
Calificadores Permitidos
Inglés
:
DE
drug effects
GE
genetics
IM
immunology
PH
physiology
RE
radiation effects
Número del Registro:
53752
Identificador Único:
D056811
Ocurrencia en la BVS
:
Similar:
DeCS